Manhattan plot from the GWAS in Zekavat et al. for expanded clonal size (defined as clonal fraction > 10%) among N = 444,199 individuals in the UK Biobank, of which N = 66,011 carried an mCA and N = 12,398 individuals carried an expanded clone. The GWAS in Zekavat et al was performed with a Wald logistic regression model with covariate-adjustment for age, age 2 , sex, ever smoking, principal components 1-10, and genotyping array. Red points represent SNPs in the expanded clonal size GWAS with a p -value < 10 −6 in the GWAS for passenger-approximated clonal expansion rate, and blue points represent SNPs in the expanded clonal size GWAS with a p -value < 10 −3 and > 10 −6 in the GWAS for passenger-approximated clonal expansion rate. These included SNPs in the genes TCL1A (chr14), TERT and NRIP1 (chr21).
