Dot plot of fold change in clonal expansion rate compared to loss of chromosome X (X-). Red dots represent a gain of chromosome, blue dots represent a loss of chromosome, and yellow dots represent CN-LOH. The PACER scores are calculated after covariate adjustment (age, sex, study cohort, and clonal fraction) and inverse normalization of the total passenger mutations for all individuals with a single mCA. The median of the PACER scores is computed for individuals with the same mCA type and location to estimate mCA fitness. The fold change in estimated mCA fitness is calculated by dividing the clonal expansion rate for a given mCA by that for a loss of chromosome X. The size of the dot corresponds to the number of individuals with that mCA type. The orange line represents the fold change of clonal expansion rate of the CHIP mutation DNMT3A with respect to X.
