Workflow from Scientific Research

The input is the sequences of the subunits in the complex. (1) Structure prediction of all pairwise and some larger subunit subsets using AFM. (2) Selection of representative subunit structures out of all predicted structures, followed by computation of all pairwise transformations present in predicted structures relative to the representative structures. (3) Combinatorial and hierarchical assembly of subunit structures using the computed pairwise transformations. In each iteration, new subcomplexes are assembled using a pairwise transformation to join two previously created subcomplexes.

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