Protein Structure from Scientific Research

Crystal structures of the three functionally active nanobodies in complex with TREK-2. The nanobodies are shown in purple as surface representations whilst TREK-2 is shown in cartoon (green and gold). For CA10767 (Nb-Activator-67) the third intracellular nanobody in the unit cell is shown in grey. A structure of the functionally inactive binder, CA10758 (Nb-Binder-58) is also shown in complex with TREK-2. In this case the nanobody binds as a dimer to the top of the Cap domain away from the extracellular TM/Pore loops that influence channel gating.

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