Chemical Structure from Scientific Research

The C9-CoA unit is synthesized by converting 2MB-CoA and two equivalents of malonyl-CoA through the functional expression of type III PKSs and two KRs. 2MB-CoA is not native to yeast but can be obtained by activating 2MB acid through CoA thioesterification, which can be supplemented directly in the culture medium or biosynthesized through an engineered type I PKS LovF-TE.

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