Activation of TRPA1 vagal (left) or DBH cNST (right) neurons rescues animals from LPS-induced sepsis. The graphs show survival curves. All groups received the same regime of CNO injections. mCherry (black lines; n = 9) and hM3Dq (green lines; n = 8 (vagal) and n = 9 (cNST)) are shown. Log-rank (MantelCox) tests: P < 0.001 (vagal) and P < 0.001 (cNST). The red arrow denotes LPS injection. All mCherry control mice, in both groups, died within the first 4 days.
