Protein Structure from Scientific Research

Cryo-EM maps of XBB.1.5 S protein trimer closed-1 state ( left ) and closed-2 state ( right ). Each protomer is colored raspberry, yellow, and light pink (closed-1) or orange, yellow, and light pink (closed-2). In the close-up views, structures of the XBB.1.5 S protein trimer closed-1 state and closed-2 state are shown in the ribbon and stick model, and the corresponding residues in the XBB.1 S closed-1 and closed-2 structures (PDB: 8IOS and 8IOT, respectively) are also shown in cyan. On the right side of the closed-1 and closed-2 cryo-EM maps, the superposition of the main chain structures of the XBB.1 and XBB.1.5 protomers are shown. Dashed lines represent hydrogen bonds.

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