Subgroup analysis of overall response rate per RECIST v1.1 by IRC review ( N = 62). IRC = Independent Review Committee, RECIST = Response Evaluation Criteria in Solid Tumors, HBV = hepatitis B virus, ECOG PS = Eastern Cooperative Oncology Group Performance Score, BCLC = Barcelona Clinic Liver Cancer, TACE = transarterial chemoembolization, HAIC = hepatic arterial infusion chemotherapy, CI = confidence interval. Macrovascular Invasion or Extrahepatic Spread included 2 macrovascular invasion only patients, 32 extrahepatic spread only patients and 5 patients had both macrovascular invasion and extrahepatic spread