The bar plot shows mRNA levels of indicated genes in dCas9-KRAB expressing smooth muscle cells with control sgRNA and sgRNA targeting around the rs10815466 lead SNP. The relative mRNA levels of all nine genes proximal or 3D linked to the rs10815466 lead SNP risk loci were measured by RT-qPCR. Two-tailed student t-tests were used for all statistical comparisons. Error bars in Fig. 5b, d indicate the standard error of the mean of three independent biological replicates ( n = 3).
