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Solicited local and systemic adverse events. Per protocol, adverse events were graded as mild/grade 1 (easily tolerated), moderate/grade 2 (interfering with daily activity), or severe/grade 3 (preventing daily activity), and in the case of fever as grade 1 (38.0-38.4 C), grade 2 (38.5-38.9 C) or grade 3 (>= 39 C). Post hoc, local adverse events were also graded according to the Food and Drug Administration (FDA) Adverse Event grading scale (Supplementary Fig. 2, Additional file 1 ), to more conservatively reflect observed local reactogenicity. If there was more than one episode per participant, the highest grade adverse event was listed. *One participant withdrew from follow-up after the first immunisation and adverse events for this participant were recorded only until 2 days after the first immunisation. The solicited systemic adverse event rash was not reported during the study

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