Fecal metabolome is altered by phenylbutazone administration. PCA of fecal metabolites grouped by treatment (NSAID or control) and day (day 0 = before NSAID administration and day 10 = after NSAID administration). Ellipses represent 95% CI around the group mean points. Point size indicates quality of representation (cos 2 ) of individuals on the PCA; the larger point size reflects higher quality representation