Representative KO genes appearing in A are shown in pathway modules modified from KEGG pathway maps Glycolysis, Lysine biosynthesis, Threonine biosynthesis, Shikimate pathway, Tryptophan biosynthesis, Menaquinone biosynthesis, Ubiquinone biosynthesis, Heme biosynthesis, GABA biosynthesis, Trans-cinnamate degradation, and Ascorbate degradation. Each box in a pathway represents a KO gene and is marked in red for elevation in Han4k_6m or in blue for depletion in Han1k_KP and Han4k_d3m. Black dots in each pathway represent intermediate metabolites. The statistical significance between two groups is marked by plus signs. The q values < 0.05 denoted as + ; the q values < 0.01 denoted as + + ; the q values < 0.001 denoted as + + +
