Significantly differential plasma metabolites in both time-altitude cohort and Tibetan4k_NP. The plus signs in column Han1k_KP, Han4k_1w, Han4k_6m, Han4k_d3m, and Tibetan4k_NP represent significance of the comparison between Han1k_KP and Han1k_HP, between Han4k_1w and Han1k_KP, between Han4k_6m and Han1k_KP, between Han4k_d3m and Han4k_6m, and between Tibetan4k_NP and Han1k_KP, respectively. The q values < 0.05 denoted as “ + ”; the q values < 0.01 denoted as “ + + ”; the q values < 0.001 denoted as “ + + + ”.