Forest Plot from Scientific Research

Mediated association of gut bacterial genera with prevalent diabetes by selected metabolites (or lipid modules) and proteins. The left forest plot shows associations of selected genera with diabetes following consecutive adjustment for selected metabolites/proteins in logistic regression. The “base model” refers to the model adjusted for age at visit, study site, race/ethnicity, household annual income, education, smoking, alcohol consumption, HIV serostatus, fasting status, and antibiotics use. “+ metabolites/proteins” refer to the models further adjusted for specific metabolites/proteins in addition to variables in the base model, while “+ All” refer to the model further simultaneously adjusted for all selected metabolites/proteins. The right panel shows proportions mediated (calculated as the ratio of indirect effects to total effects) of examined metabolites (or lipid modules) and proteins in regression-based mediation analysis (see “ Methods ”).

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