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Recommended Method Combinations Dependent on Experimental Design. Method combinations are provided for different experimental designs, including those that are not multiplexed (left) and multiplexed (right), including experiments that have reference SNP genotypes available vs those that do not and finally, multiplexed experiments with different numbers of individuals multiplexed. The each bar represents either a single method (shown with the coloured icon above the bar) or a combination of methods (shown with the addition of the methods and an arrow indicating the bar). The proportion of true singlets, true doublets, false singlets and false doublets for each method or combination of methods is shown with the filled barplot and the MCC is shown with the black points overlaid on the barplot. MCC: Matthew’s Correlation Coefficient

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