Protein Structure from Scientific Research

Alignment of the C-terminal tails of 3CLpro in the M49K/S301P structure (colored cyan) with that in the mature WT 3CLpro structure (colored orange). In the M49K/S301P mutant, the Φ angle of P301 is fixed, and therefore, the C-terminal tail of 3CLpro is locked at the post-cleavage state.

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