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Huntingtin (HTT) defects as caused by the mutations that drive Huntington’s disease (HD) foster a robust neuroinflammatory process involving microglial cells as well as astrocytes and oligodendrocytes that is often associated with a TH17-polarized CD4 + T cell response dominated by the secretion of pro-inflammatory cytokines like interleukin 8 (IL8), IL17A and tumor necrosis factor (TNF). BBB blood brain barrier, mHTT mutant huntingtin. Created with BioRender.com.

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