Uptake of the primary three doses of RTS,S, in relation to use of LLINs, malaria transmission intensity, socioeconomic status, and sex. Vertical bars indicate 95% CIs. The percentage that slept under an LLIN the night before the survey was 67% in Ghana, 93% in Kenya, and 68% in Malawi. RTS,S uptake was documented from a home-based record (in 92% of children in Ghana, 88% in Kenya, and 91% in Malawi) or from caregiver recall for those without a record. Malaria prevalence was categorised according to tertiles of malaria prevalence among children aged 5-48 months. Wealth was categorised according to tertiles of principal component scores based on household assets. The prevalence ratios (and 95% CIs) in the proportion of children who had received the third dose of RTS,S between categories were 1.20 (1.05–1.38) in Ghana, 1.23 (1.01–1.50) in Kenya, and 1.20 (1.04–1.37) in Malawi for LLIN users compared with non-users; 1.04 (0.92–1.18), 1.00 (0.84–1.20), and 0.84 (0.69–1.02) for higher malaria prevalence compared with lower; 1.00 (0.88–1.13), 1.18 (1.04–1.35), and 1.04 (0.90–1.19) for upper wealth ranking compared with lower wealth ranking; and 1.06 (0.97–1.15), 1.01 (0.90–1.13), and 1.07 (0.99–1.16) for girls compared with boys. LLIN=long-lasting insecticide-treated net. RTS,S=RTS,S/AS01Emalaria vaccine.