Protein Structure from Scientific Research

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Contacts between MAT1 and the tip of CDK7 T-loop contribute to an activated state of CDK7. The tip of the CDK7 T-loop harbors a second T-loop phosphorylation site at S164, in addition to the conserved CDK T-loop phosphorylation site at CDK7 T170 (which was not phosphorylated in the cryo-EM structure).
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