Simulation snapshots showing several lipids (colored in yellow, orange, red, and purple) translocating along the scrambling pathway of MTCH2. The protein is shown as a molecular surface colored according to the character of its residues (hydrophilic = green, hydrophobic = white, positively charged = blue, negatively charged = red). Bulk lipids are depicted as gray beads (phosphate group) with hydrophobic tails omitted for clarity. Water is represented only schematically as a blue gradient, omitting the presence of water in the cavity of the protein for visual clarity.
