Cartoon structure of MTCH2 at the start of the simulation (in gray) overlaid with the structure of MTCH2 at the end of the 3 μs atomistic simulation (in orange). Note that the α-helical segments of the protein were quite stable and they did not significantly reorient or reposition during either of the simulations. This suggests that the predicted structure is stable and the protein cavity and the scrambling pathway remain open.
