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The methods are evaluated on the described symmetries within all TM chains in the set (internal symmetry) and within all complexes with >1 membrane-spanning chain (quaternary symmetry): in total, 118 and 74 symmetry descriptions, respectively. The percentage of symmetries identified correctly, which is the sum of the true-positive and true-negative rates (Tables S1andS2), as well as the false-positive rate are shown for each method (Order and Coverage). In cases where a method detects the symmetry described in the benchmark but reports a symmetry repeat that is only part of the benchmark repeat, i.e., it is missing at least 20 consecutive residues, the correct rate is shown in lighter color (Order only).
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