Structure and sequence similarity for all proteins that have been compared to the structure of interest. Each compared protein chain is represented as a point indicating its similarity according to both the MUSCLE sequence alignment (as fraction identical residues) and the FrTM-Align structure-based alignment, where the latter is defined using the so-called template modeling score (TM-score). The histograms along the side and top report the distributions of the points in the graph, summed for each axis. Data points are colored based on the difference in the number of TM segments between the structure of reference and the structure being compared, following the legend, with bluer shades indicating that the structural neighbor has more TM elements, and redder shades indicating that the neighbor has fewer TM elements. The background contours indicate the structural and sequence similarity of all compared pairs of chains in the EncoMPASS dataset. Contours indicate the probability density of the pairwise alignments having a given value of sequence identity and structural similarity.
