Phosphatase activity of 50 nM SHIP1 against either I(1,3,4,5)P4(left) or PI(3,4,5)P3-DiC8 (right). Initial rates have been plotted as phosphate produced per second per molar concentration of enzyme. There are no significant differences in the catalytic activity in the presence (black circles) or absence (red circles) of the C2 domain for either substrate.
