Line Plot from Scientific Research

Skilled forelimb grasp training was performed, demonstrating significant improvement in pellet retrieval accuracy to >80% (***p < 0.001, repeated-measures ANOVA). Rats underwent repeated testing 2 weeks later to ensure persistence of retrieval ability, followed by intraperitoneal injections of either DT in 6 animals that expressed the DTR and 3 controls that did not or saline in 7 controls that expressed DTR. DT injections are indicated by yellow arrowheads. Two weeks later, only animals expressing DTR that received DT injections demonstrated a significant reduction in grasping performance (***p < 0.001, ANOVA).*p < 0.005 indicates significant loss of grasping accuracy among animals with DTR + DT injections after DT injections compared to both control groups.*p < 0.05 indicates significant difference in pre-DT performance compared to post-DT performance in the DTR + DT group. The averages of days 32–35 and 48–49 were compared for statistical analysis. All error bars represent standard errors.

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