Protein Structure from Scientific Research

Subunits of representative subfamily members viewed from the extracellular side. Cartoons are colored by ConSurf32 score based on the corresponding GR subfamily sequence alignment. Ca spheres mark predicted pocket-lining residues labeled with their residue numbers in the reference protein and heatmaps capturing amino acid-type frequencies at that position in the corresponding alignment (left to right are aliphatic [Ala, Cys, Leu, Met, Val; black], polar [Asn, Gln, Ser, Thr; orange], negatively charged [Asp, Glu; red], positively charged [Arg, Lys; blue], aromatic [His, Phe, Trp, Tyr; green], or shape-determining [Gly, Pro; pink] residues). The following (sub)families and corresponding subunits are illustrated: OR family on agonist-free MhOr5.

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