Subunits of representative subfamily members viewed from the extracellular side. Cartoons are colored by ConSurf32 score based on the corresponding GR subfamily sequence alignment. Ca spheres mark predicted pocket-lining residues labeled with their residue numbers in the reference protein and heatmaps capturing amino acid-type frequencies at that position in the corresponding alignment (left to right are aliphatic [Ala, Cys, Leu, Met, Val; black], polar [Asn, Gln, Ser, Thr; orange], negatively charged [Asp, Glu; red], positively charged [Arg, Lys; blue], aromatic [His, Phe, Trp, Tyr; green], or shape-determining [Gly, Pro; pink] residues). The following (sub)families and corresponding subunits are illustrated: Gr43a subfamily on agonist-free BmGr9.
