A proteomic screen of viral single-gene-deletion mutants determined that US33A is necessary for downregulation of DMXL1 (each virus was used at MOI = 7.5, n = 2, 60 h infection). Fold change (FC) was calculated from the average signal:noise for both US33 biological replicates divided by the average signal:noise for both control replicates. TheZscore was calculated as described inFigure S1. See alsoTable S3.