Heatmap analysis of selected metabolite markers for chikungunya patients (D, deaths; S, survivors; C, chikungunya cases from both outcomes) compared with healthy blood donors (H) shows the log2FC and the p value. The log2-fold changes (log2FCs) are scaled from blue (low intensity) to red (high intensity). Statistical analyses were performed using the Wilcoxon test in MetaboAnalyst.27