Guide to coloring of the various subunits within the neddylated CRL2VHL-MZ1-BRD4 (346–460)-UBE2R2ubiquitin cryo-EM structure. BD2 represents the second bromodomain of the BRD4 protein spanning residues 346–460. The UBE2R2 active site Cys residue is denoted as C93 (yellow star). UBE2R-family members have a highly conserved, acidic tail located at the C terminus not present in other human E2s. ELOB, ELONGIN B; ELOC, ELONGIN C; UBD, ubiquitin.
