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Scheme explaining the effect of cofactors on the degradation of Ub(n)-REFOLD in (E). Substrate refolding (black arrow) competes with degradation. Ubx5 recruits folded substrate to Cdc48-UN, Shp1 stimulates substrate unfolding, and Rad23 recruits unfolded substrate to the proteasome.
#Workflow#Flowchart#Illustration#Ub(n)-REFOLD#Cofactors#Substrate Degradation#Substrate Refolding#Ubx5#Cdc48-UN#Shp1#Rad23#Proteasome
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