Histograms showing the log fold changes inkon,koff, andsas well as the changes in the average fraction of time that genes spend in the active state (kon/(kon+koff)) during the time course. (Wilcoxon paired tests p < 10-15for allkon,s, andkon/(kon+koff) comparisons of naive ES vs. 24 h and 24 h vs. primed cells. The values forkoffwere p < 3.9 x 10-12when comparing naive ES and 24 h cells and 5.8 x 10-5when comparing 24 h and primed cells.) Related toFigures S6andS7.