Saddle plots showing the normalized average A/B compartment interaction frequencies between pairs of 25 kb bins, arranged by their A or B compartment Cscores (seeSTAR Methodsfor the definition of the Cscore). The bar charts show the average normalized Cscores from within the boxed A/B compartment regions. Bootstrap estimates of the standard deviation were obtained from 200 random samples of 20% of the data.