Microscopy from Scientific Research

Open access visualization of Microscopy, Translocation, SPG20, Damaged Lysosomes, Hydrophobic Residues
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DOI: 10.1016/j.molcel.2024.02.029

DOI

Translocation of SPG20 to damaged lysosomes depends on bulky hydrophobic residues in the SC domain. Cells expressing GFP-tagged versions of SPG20 wt, 6xV, 8xV, or 23xV mutant were mock or LLOMe-treated and costained for LAMP1 and Gal3.

#Microscopy#Translocation#SPG20#Damaged Lysosomes#Hydrophobic Residues#SC Domain#Cells#GFP-Tagged Versions#Mutant#LAMP1#Gal3#Staining

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