Heatmap from Scientific Research

Cervical cross sections from mirror blocks (https://www.brainbank.nl/nbb-ms/characterization-of-ms-lesions/) of samples in (A), used forXenium in situ sequencing, depicting binned expression ofMOGandHLA-DMBtranscript density. Dashed lines outline regions with upregulatedHLA-DMBexpression (active lesions) and downregulatedMOG(inactive lesions). Numbers correspond to pathological lesion staging. The white arrows mark aMOG-depleted area (MSi2) andHLA-DMBenriched areas (MSa2), pathologically not annotated as lesions. Scale bars, 1,000 μm.

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