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Experimental strategy. Oligodendrocytes (OL; n = 66 PTA, n = 20 MDA) and neurons (n = 56 PTA) were obtained from the brains of 20 neurotypical individuals (0104 years of age) through FANS using NEUN (neurons) and SOX10 (OL) antibodies. Single genomes were amplified using PTA or MDA and non-clonal somatic SNVs (sSNVs) and indels were called using SCAN2. Mutation distributions were compared with snATAC-seq and snRNA-seq data obtained from a subset of the 20 individuals.

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