Boxplot of bacterial richness of patients receiving immunotherapy between the first and second biopsy, stratified based on whether the patients were non-responsive (progressive disease [PD] according to RECIST1.1; left) or responsive (stable disease [SD], partial response [PR], or complete response [CR]; right). The pairedpvalues shown in (C) and (D) were determined using thebetta_randomframework, adjusted for time between biopsies, primary tumor location, and lesion status. See alsoFigure S7.
