Graphic representation of Spearman’s rank correlation of pairwise analysis of fecal calprotectin, BMI, and moisture values against absolute species abundance (QMP) and RMP from the LCPM (N = 589) and FGFP (N = 1,045) cohorts (adjusted P < 0.05, Supplementary Table 8 ). The species enriched or depleted in relation to CRC diagnosis groups were tested using QMP, CLR and RMP data before (n = 589, two-sided KW test and Spearman’s rank correlation comparison, adjusted P < 0.05) and after controlling for microbiota covariates (before adjustment for BMI, calprotectin and moisture; generalized linear model ANOVA, adjusted P < 0.05).