Fraction of total CD8 + T cells (left), CD8 + GrzB + effector T cells (center) and CD8 + GrzB - T cells (right) in the peripheral blood of responding (≤50% viable tumor cells in resected tumors and lymph nodes) and nonresponding patients (>50% viable tumor cells). Each dot represents an individual patient: baseline values are in black and values at day 28 are in red. Whiskers and boxes represent the minimum, first, second and third quartiles and the maximum. Wilcoxon matched pairs signed-rank test was applied for statistical comparison. All P values are two-sided, no adjustments were made for multiple comparisons.
