Comparison of PFS from the previous regimen (orange in bar graph) and trial regimens for both FPM-guided (blue in bar graph) and TPC (black in bar graph) cohorts, with indications for patients with a PFS ratio of ≥1.3× (light green boxes above indicated patients) and <1.3× (light red boxes above indicated patients). P value determined by two-sided Barnard’s test analysis of occurrences of PFS ratio of ≥1.3×.