Difference in PFS of the previous regimens and trial regimens for FPM-guided (left) and TPC-treated (right) cohorts. Asterisk, five patients who received TPC and had the same previous and trial regimen PFS. P values for each cohort determined by two-sided paired Wilcoxon test. P value between cohort determined by two-sided Mann–Whitney U -test of PFS ratio values. Light green dots indicate patients with a PFS ratio of ≥1.3× (top), light red dots indicate patients with a PFS ratio of <1.3×, and orange dots indicate the PFS of the previous regimen for both cohorts.
