Line Plot from Scientific Research

Sample size in each group: NGT, n = 767; insulin-resistant GDM, n = 34; insulin-deficient GDM, n = 19; and mixed defect GDM, n = 12. Lines represent the levels of circulating IGFBP1 (not transformed) from the first trimester visit to the late second trimester visit at exact gestational age of the measure, smoothed by a generalized additive model with parameter estimation via restricted maximum likelihood using stat_smooth function from the ggplot2 package. Shaded areas represent 95% CIs.

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