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Linear regression of continuous traits in individuals carrying 1, 2 or 3+ rare pLoF, deleterious missense or multigenic variants overlapping dominant DDG2P genes, compared to the rest of UKB (that is, noncarriers). values for continuous traits were measured as follows: fluid intelligence, standardized units (ranging from 1-13); age left education and years in education, years; height, cm; reaction time, time taken on pairs test, numeric memory, income, and TDI, standard deviations from the mean. Data are presented as mean values 95% CI, where solid lines indicate that the P value reached Bonferroni-corrected significance and dashed lines indicate that it did not. P values were not corrected for multiple testing.

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