Manhattan Plot from Scientific Research

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Miami plot of cirrhosis GWAS. The x axis is the chromosomal location of SNPs and the y axis is the strength of association -log10(P). Note that the y axis includes a break at 50. The lead SNPs and SNPs located within 1 Mb are highlighted, and the nearest genes are annotated. The top plot shows results from the European-specific GWAS meta-analysis, whereas the bottom plot displays results from the cross-ancestry GWAS meta-analysis. The dashed red line represents the threshold for genome-wide significance (P < 5 x 10 -8). P values were two-sided and based on an IVW fixed-effects meta-analysis, and not adjusted for multiple testing.
#Manhattan Plot#Miami Plot#Cirrhosis#GWAS#SNPs#Chromosomal Location#Meta-Analysis#European#Cross-Ancestry#Genome-Wide Significance
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