Miami plot of cirrhosis GWAS. The x axis is the chromosomal location of SNPs and the y axis is the strength of association -log10(P). Note that the y axis includes a break at 50. The lead SNPs and SNPs located within 1 Mb are highlighted, and the nearest genes are annotated. The top plot shows results from the European-specific GWAS meta-analysis, whereas the bottom plot displays results from the cross-ancestry GWAS meta-analysis. The dashed red line represents the threshold for genome-wide significance (P < 5 x 10 -8). P values were two-sided and based on an IVW fixed-effects meta-analysis, and not adjusted for multiple testing.
