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CuSOD ESM-1v and ProteinMPNN scores for round 3 selected passing (teal) and control (violet) sequences. The vertical dashed gray line indicates the top 10th percentile cutoff for ESM-1v score calculated from the test sequences. Horizontal dashed lines are the ProteinMPNN scores of the 40th-ranked sequences among the 200 selected sequences sequences for which the scores were calculated for each model-family combination, including ProteinGAN (lower, green) and ESM-MSA (upper, red). Control sequences to the right of the gray line are possible if they failed one of the quality checks.
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