Time course of fibrin fluorescence intensity and total thrombus volume (left) and bar chart quantification of average fibrin intensity and average thrombus volume (right) for control animals (n = 7), argatroban-treated animals (n = 4; 2 mg per kg (body weight) bolus followed by an infusion of 12 mg per kg (body weight)) and A1E1-treated animals (n = 5; 5 mg per kg (body weight) bolus). Statistical significance between multiple treatment groups was analyzed using an ordinary one-way analysis of variance (ANOVA) with Tukeys multiple comparisons testing with a single pooled variance. For multiple comparisons testing, the mean of each column was compared to the mean of every other column. Data are presented as mean s.e.m., where n equals the number of independent experiments performed; NS, not significant (P = 0.6660 for average fibrin intensity and P = 0.5128 for average thrombus volume); ** P = 0.0025; **** P < 0.0001; AU, arbitrary units.
