Cosine similarity between compounds and the two genetic perturbation modalities, CRISPR (orange) and ORF (green) targeting the same gene or gene product. All analyses here were also statistically significantly more positively correlated; P values are available in Supplementary Table 4 . Cosine similarity of zero is shown as a gray dashed line in both subplots. In a there were n = 3,728 biological independent ORF and CRISPR reagents and in b there were n = 1,864 independent pairs of compounds and genetic perturbations targeting the same gene or gene product. Box plot boundaries are 75th (Q3) and 25th (Q1) percentiles, with whiskers at 1.5-fold the interquartile range (Q3Q1) or the highest or lowest data point.
