Each rectangular block of replicates (REPLICATE X or REP X) is a 384-well plate of cells perturbed by compounds, CRISPR guides or ORFs and subjected to different experimental conditions. Short and long time points are described in Supplementary Table 1 . Plates in the vertical blue and green boxes comprise the primary CPJUMP1 experiment. The other (that is, secondary) experimental conditions are described in the Methods section.
