Ex vivo phagocytosis with neutrophils and monocytes, respectively, at MOP 25. For ( I ) and ( J ), repeated measures one-way ANOVA was used with Dunnett’s post hoc test after multiple comparisons and compared against IgG3. The data points in ( B )–( J ) represent the mean value, and the error bars are in SEM. The phagocytosis score seen in ( I ) and ( J ) is normalized to Ab25 IgG1 for each experiment. In ( F )–( J ) N = 6 independent experiments were performed. R 2 = 0.99 for all non-linear regression curves. Statistical analyses for ( F )–( H ) were done by comparing IgG1 with one-way ANOVA multiple comparisons corrected by Dunnett’s correction test. * denotes p -value < 0.05, ** denotes p -value < 0.01, and p -value > 0.05 is ns. Source data are provided as a Source Data file.
