Protein Structure from Scientific Research

Left, computational analysis of long-range communication in Anc5ΔLoop I. Cartoon representation of Anc5ΔLoop I with cartoon_tube representation of loop II to VI (shown in green, slate, purple, orange, and cyan, respectively). Sphere representation indicates 45 substitutions residues (purple) and two glutamic acids and one serine that holds catalytic water (magenta). Right, rigidity-transmission allostery (RTA) communication analysis on Anc5ΔLoop I. Residues are colored based on the intensity (red being highest) of long-range rigidity-transmission communication with loop II (green). Spheres indicate 45 substitutions.

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